Griffiths RR, Johnson MW, Carducci MA, Umbricht A, Richards WA, Richards BD, et al. Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: a randomized double-blind trial. J Psychopharmacol Oxf Engl. 2016;30(12):1181–97. The dosage of psilocybin to ingest depends on many factors. Different people will respond differently to the same dose of psilocybin, and the same person might respond differently to the same dose on different days. This is why any suggested dosages are just guidelines, and you should always dose with caution until you learn your preferred range. Researchers searching for the LD50 for psilocybin noted exceptionally high go now doses compared to other compounds. The LD50 data for psilocybin is reported to be as high as 280 mg/kg .